Tumour cell teamwork

Granular cell tumour (Abrikossoff’s tumour): Case series

This case series describes three unreported cases of an uncommon benign neoplasm named Abrikossoff’s tumour or granular cell tumour (GCT). This mesenchymal neoplasm apparently arises from neural or Schwann cell origin with benign and malignant forms. All cases presented here were unique nodules on oral mucosa, coming out from the connective tissue, and occurring in women with age ranging from 3...

Tumour radiobiology beyond fractionation

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

Bone: Giant cell tumour

Rib Giant Cell Tumour

A 55 year old woman was admitted because of a slowly growing chest mass. A diagnosis of giant cells tumor (GCT) was made. In sharp contrast to other large bone metaphysis it accounts for < 1 % of all primary rib’s neoplasias. The resection included one normal adjacent rib above and below the tumour with all intervening intercostals muscles and pleura and the adjacent cartilages. Reconstruction ...

Vinculin, cell mechanics and tumour cell invasion.

The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, an...